The AND-PD project aims to improve the diagnosis, management and treatment of anxiety as a co-morbidity of Parkinson's disease (PD) through greater understanding of its neurobiological causes

There are 10 work packages in the AND-PD project

1

Defining the phenotype of comorbid anxiety/depression in PD animal models  

2

 Defining the neural circuitry that underlies comorbidity 

3

Disruption of neural circuitry to cause co-morbidity

4

Rescue co-morbidities with novel RNA based neuroprotection and circuit interventions in the mid-brain that restore the functional role of specific neurons. 

5

Molecular characterisation of PD co-morbidities

6

Linking mid-brain degeneration with anxiety/depression symptoms in post-mortem PD brain samples 

7

Mid-brain functional connectivity in PD patients

8

Clinical phenotyping and risk factors of comorbidities in patients 

9

Dissemination and Exploitation 

10

Consortium Management and Governance 

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